While positive results from PRP treatment are not guaranteed, meaning that some patients may experience a significant reduction in their pain, some may have mildly reduced pain, and some patients, unfortunately, may experience no relief at all.  A high-quality study, performed in 2013, found that 83.9% of the patients in the trial that received PRP reported pain reduction of 25% or more 24 weeks after their treatment (Mishra et al. 2013). The success rate for pain reduction with PRP treatment varies from condition to condition, but typically lies in the range of 60-93%, depending on the study consulted.  Pain reduction typically lasts for approximately 12 months.