Clinical Trials

Investigator Initiated Trials

Wilderman Medical Clinic strives to be at the forefront of research and innovation. Our investigator-initiated trials are lead by qualified staff and by physician researcher with over 10 years of clinical research experience. Similarly to industry-initiated trials, physician-initiated trials have to go through the approval process, data collection and analysis, and can take up to several years. The goal of our trials is to analyse data collected over many years, as well as prospectively, and establish patterns that can potentially be used to establish more efficient methods, treatment approaches and measuring tools for delivering care to patients with chronic pain.

Wilderman Medical Clinic is currently looking to recruit volunteers with chronic pain conditions for the following studies:

Wilderman Medical Clinic is conducting a study to provide evidence of the validity of a new pain measurement tool. This tool will be used for the evaluation of the treatment effectiveness of corticosteroid injections for pain relief in patients with osteoarthritis of the knee. Osteoarthritis produces pain in the knee that is typically worsened by activities such as long distance walking. Corticosteroid injections into the knee joint are usually prescribed to treat the pain associated with osteoarthritis.

There are currently no well-established tools that can accurately measure the percentage and duration of pain relief. The new, developed within Wilderman Medical Clinic, Integral of Pain Relief (IPR) is a pain measurement tool that assesses two significant pain relief dimensions: (1) the percentage of pain relief, and (2) the duration of pain relief. Both factors are reported by the patient and provide important information about whether and to what extent a treatment provides relief for patients.

Benefits to participate in the study:·

  • Your medical condition will be closely monitored during study period.
  • You will receive an individual pain diary. Keeping this pain diary helps to improve overall pain management, allows the assessment of pain dynamics, and gives a better understanding of what works best to alleviate your pain.
  • Your family doctor will be updated in case of a change in your health condition.
  • Your participation with us will help to improve pain relief interventions and treatment plans for other patients with chronic pain conditions like osteoarthritis of the knee.

Preliminary eligibility criteria

  • You must be available to participate in this trial for up to 13 weeks.
  • You must be over the age of 40.
  • You must have a confirmed diagnosis of knee osteoarthritis and have knee pain  more than 15 days in a month.
  • You must regularly receive corticosteroid injections or have considered receiving corticosteroid injections into the knee joint.

Further requirements will be reviewed with the doctor and trial personnel at the next stage and the evaluation.

To find out if you are eligible to participate in this study, please call (905) 886-1212 ext: 204 or e-mail: [email protected]

Wilderman Medical Clinic is conducting a study on patients’ experiences with  Botox for chronic migraine.We want to better understand patients’ experience with treatment for chronic migraine so that we can help to make treatment procedures better, and help inform future research for migraine treatment. We want to better understand why patients choose particular treatments, what they find effective, and why.

What you can expect

This research will involve your participation in a single telephone interview that will take approximately 30-60 minutes. During the interview, we will talk about your experience with chronic migraine and the treatment you have received.

Benefits of participation

  • Your participation may benefit you by being able to share your treatment journey.
  • Your participation will help us find out more about how patients view their treatment and their reasons for beginning, continuing, or discontinuing treatment.
  • This information will benefit future patients as it will inform future research and treatment for chronic migraine.

Preliminary eligibility criteria

  • 18 years of age or older
  • Have had at least one prophylactic treatment with Botox for chronic migraine


  • Have been recommended for prophylactic treatment with Botox for migraine, but did not go ahead with this treatment

Further requirements will be reviewed with trial personnel at the next stage of evaluation.

To find out if you are eligible to participate in this study please email [email protected] or call (905)-886-1212 ext. 206

Our Completed Studies and Publications

Wilderman Medical Clinic reviewed and analyzed the clinical database of patients whose pain was treated with lidocaine infusions. Our study results demonstrated that increased doses of intravenous lidocaine are effective and safe in a significant number of patients with fibromyalgia. With higher doses of lidocaine pain relief was sustained in duration and lasted longer after the treatment. The results of this study were published in the Journal of Pain Medicine in 2019 (1). The full text of the article is available on our website.

1 Igor Wilderman, MD, CCFP, FCFP, DAAPM, Olga Pugacheva, PhD, Vsevolod (Sev) Perelman, MD, MSc, CCFP(EM), FCFP, CEUS, CHSE-A, Michael C T Wansbrough, MD, MSc, CCFP(EM), CEUS, DTM&H, DLSTMH CHSE, Yuri Voznyak, HBSc, Lukasz Zolnierczyk, HBSc, Repeated Intravenous Lidocaine Infusions for Patients with Fibromyalgia: Higher Doses of Lidocaine Have a Stronger and Longer-Lasting Effect on Pain Reduction, Pain Medicine, pnz251,

Canadian Centre for Clinical Trials

If you are interested in learning about our current industry-initiated trials please visit our website

If you are a healthy individual and want to contribute to the clinical trials community, please follow the link:

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